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Do you suffer from Rheumatoid Arthritis despite trying multiple medications?

If so, you may qualify for the RESET-RA study, which is evaluating a novel treatment option for Rheumatoid Arthritis (RA) by activating the vagus nerve in the body.

The RESET-RA study is designed to determine if an investigational vagus nerve stimulation device is safe and can improve RA in people who continue to experience symptoms even after they have tried multiple medications.

Neurostimulation as an alternative

Scientists have recently discovered that applying a small amount of electrical impulses (stimulation) to the vagus nerve activates a neurological pathway that may decrease the type of excess inflammation that is the underlying cause of RA.1

1 Koopman et al, Proc Natl Acad Sci USA. 2016;113:8284-9.

Thank you for your interest in the RESET-RA Study. Enrollment in the study has concluded. 

The next phase of the study is to follow the current participants to determine the outcomes of the study.  While we await the results, we have partnered with the Global Healthy Living Foundation (GHLF) to keep you up to date on the study and provide additional educational resources for management of RA. 
Please visit for a community of support, free resources, and tools to help you live better with RA.
As the parent organization of CreakyJoints®, a worldwide digital community serving millions of arthritis patients and caregivers, GHLF provides free education, support, advocacy, and patient-centered research in both English and Spanish.

What is the implant procedure like?

Watch a quick video that explains the surgical procedure to implant the device.

What to expect when participating in RESET-RA?

Learn more about how your commitment will contribute to advancements in new RA treatments.

Why participate in a clinical trial?

Understand the considerations and benefits of being a part of advancing science.